Macrophages and Uveitis in Experimental Animal Models
نویسندگان
چکیده
منابع مشابه
Macrophages and Uveitis in Experimental Animal Models
Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in e...
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The mouse model of experimental autoimmune uveitis, induced by immunization of mice with the retinal protein IRBP, was developed in our laboratory 20 years ago and published in 1988. Since that time it has been adopted by many investigators and has given rise to many studies that helped elucidate genetic influences, dissect the basic mechanisms of pathogenesis and test novel immunotherapeutic p...
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The model of experimental autoimmune uveitis (EAU) in mice and in rats is described. EAU targets immunologically privileged retinal antigens and serves as a model of autoimmune uveitis in humans as well as a model for autoimmunity in a more general sense. EAU is a well-characterized, robust, and reproducible model that is easily followed and quantitated. It is inducible with synthetic peptides ...
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Uveitis of putative autoimmune origin comprises a heterogeneous group of sight-threatening diseases prevalent in the US and worldwide. Several animal models, representing various forms of uveitis, have been developed. These models reproduce distinct aspects of human disease and can serve to study basic mechanisms and as templates for therapy. ‘Humanized’ models have recently become available th...
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Murine experimental autoimmune uveitis (EAU) is a model of human uveitis. Ocular-infiltrating macrophages play a crucial role in the generation of tissue damage in EAU. In fact, several chemokines are actually produced in the inflamed eye. The aim of this study was to elucidate the role of ocular macrophage-derived chemokines in EAU. C57BL/6 mice were immunized with human interphotoreceptor ret...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2015
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2015/671417